Medikaman

To reduce the development of drug-resistant  and maintain the effectiveness of ZITHROMAX^® (azithromycin) and other  drugs, ZITHROMAX (azithromycin) should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

ZITHROMAX (azithromycin for injection) contains the active ingredient azithromycin, an azalide, a subclass of  antibiotics, for  injection. Azithromycin has the chemical name (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O -methyl-a-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14- hepta-methyl-11-[[3,4,6-trideoxy-3-(dimethylamino) -b-D-xylo-hexopyranosyl]oxy]-1- oxa- 6-azacyclopentadecan-15-one. Azithromycin is derived from ; however, it differs chemically from erythromycin in that a methyl-substituted   is incorporated into the lactone ring. Its molecular formula is C₃₈H₇₂N₂O₁₂, and its molecular weight is 749.00.

Azithromycin has the following structural formula:

Azithromycin, as the dihydrate, is a white crystalline powder with a molecular formula of

C₃₈H₇₂N₂O₁₂· 2H₂O and a molecular weight of 785.0.

ZITHROMAX (azithromycin for injection) consists of azithromycin dihydrate and the following inactive ingredients: citric acid and  hydroxide. ZITHROMAX (azithromycin for injection) is supplied in lyophilized form in a 10-mL vial equivalent to 500 mg of azithromycin for intravenous administration. Reconstitution, according to label directions, results in approximately 5 mL of ZITHROMAX for intravenous injection with each mL containing azithromycin dihydrate equivalent to 100 mg of azithromycin.